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The Hilar Cholangiocarcinoma (Klatskin Tumor)


Yigang Luo

Transplantation and Hepatobiliary Pancreatic Surgery, University of Saskatchewan, Ellis Hall, Rm161, 103 Hospital Drive, Saskatoon SK S7N 0W8, Canada

Correspondence to Author: Yigang Luo


Hepatic hilar cholangiocarcinoma was initially reported by Altemeir in 1957 [1]. Klatskin [2] reported a series of 13 cases of hepatic hilar cholangiocarcinoma in 1965. About 60% of cholangiocarcinomas are composed of this tumor. Anatomically speaking, this tumor is located at a unique location, namely the hilar biliary bifurcation within a constrained tiny space. the liver (particularly the caudate lobe) and veins (portal vein, hepatic artery). Biology-wise, it often grows slowly and locally, with lymph node metastases, submucosal infiltration (up to 1.6 cm from the tumor's gross margin), and neurovascular infiltration; distant metastasis occurs less frequently.
In terms of treatment, it is typically difficult to resect, particularly when attempting a R0 resection, and it does not react well to chemotherapy or radiation therapy. The high rate of local recurrence (>50%) causes therapy failure and unfavorable results.


Yigang Luo. The Hilar Cholangiocarcinoma (Klatskin Tumor). World Journal of Clinical Surgery 2023.

Journal Info

  • Journal Name: World Journal of Clinical Surgery
  • Impact Factor: 2.709**
  • ISSN: 2766-6182
  • DOI: 10.52338/wjsurgy
  • Short Name: WJCSR
  • Acceptance rate: 55%
  • Volume: 6 (2024)
  • Submission to acceptance: 25 days
  • Acceptance to publication: 10 days


  • Crossref indexed journal
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